work done in italy
ramazzini institute Bologna italy on glyphosate
their associates:
Boston College, de la George-Mason University, du King’s College de Londres ou encore de l’Icahn School of Medicine at Mount Sinai, à New York.
https://www.mediapart.fr/journal/ecologie/130625/glyphosate-une-nouvelle-etude-confirme-le-risque-de-cancer
first fortnite for a euro, thereafter, 12 euro per month .. the price of independence
https://ibba.cnr.it/en/senza-categoria/il-verdetto-sul-glifosato-e-definitivo-un-contributo-italiano-tra-i-piu-autorevoli-al-mondo/
https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01187-2
Andrea Vornoli, researcher at the CNR’s Institute of Agricultural Biology and Biotechnology (IBBA),
https://www.greenme.it/salute-e-alimentazione/salute/glifosato-il-verdetto-definitivo-lo-studio-storico-italiano-conferma-il-rischio-di-cancro/
https://www.lemonde.fr/planete/article/2025/06/12/glyphosate-la-plus-vaste-etude-animale-conduite-a-ce-jour-met-en-evidence-des-risques-accrus-de-diverses-tumeurs_6612420_3244.html?random=1998192473
Glyphosate : la plus vaste étude animale conduite à ce jour confirme des risques accrus de cancers
Une équipe internationale de chercheurs a testé les effets du célèbre herbicide sur plus d’un millier de rats de laboratoire à différents dosages. Dans tous les cas de figure, les scientifiques ont enregistré un surcroît de tumeurs.
Par Stéphane Foucart
Publié le 12 juin 2025
june 10th .... 59k Accesses // 9 Citations
https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01187-2
https://ehjournal.biomedcentral.com/counter/pdf/10.1186/s12940-025-01187-2.pdf
To evaluate our findings in a broader context, we note that over the past half-century, the incidence of childhood cancers has increased by 35% [81] and epidemiological evidence and mechanistic studies suggest that maternal exposure to pesticides is associated with an increased risk of childhood leukemia [70, 82], as previously suggested also by a working group organized by the European Food Safety Authority [83]. Recent epidemiologic studies have expanded the knowledge of the human carcinogenicity of glyphosate and GBHs. A recent meta-analysis reports that GBHs are associated with a 41% increased relative risk of non-Hodgkin lymphoma among highly exposed individuals [84]. Skidmore et al. [85] showed a significant temporal and geographical relationship between expansion of glyphosate tolerant genetically modified soy cultivation in the Brazilian Amazon and Cerrado regions and deaths from acute lymphoblastic leukemia in children, one of the most common pediatric blood cancers. Hardell et al. [86] published the results of a pooled analysis of three Swedish case–control studies including 1425 cases and 2157 controls, examining exposures to phenoxyacetic acids and glyphosate in relation to non-Hodgkin lymphoma and has shown an association between non-Hodgkin lymphoma and exposure to these herbicides.
results achieved studying labrats their entire lifespan .. and not, as is labcreep habit, dumping them at maturity, this one lasted 104 weeks
in 2018 the same author did a 13w one
Historical evidence of glyphosate exposure from a US agricultural cohort
In response to the recent review by Gillezeau et al., The evidence of human exposure to glyphosate: A review, Environmental Health 1/19/19, here we report additional glyphosate biomonitoring data from a repositor...
Authors: Melissa J. Perry, Daniele Mandrioli, Fiorella Belpoggi, Fabiana Manservisi, Simona Panzacchi and Courtney Irwin
Citation: Environmental Health 2019 18:42
Content type: Letter to the Editor Published on: 7 May 2019 ----------- https://ehjournal.biomedcentral.com/counter/pdf/10.1186/s12940-019-0474-6.pdf
by the way, .. very strangely, of the 101 refs [no Seneff, unsuprisingly] only a few light up with a link, an epa report for instance, and this one:
Stout L, Ruecker F. Chronic study of glyphosate administered in feed to albino rats. Unpublished Study, Project No MSL-10495 Monsanto Agricultural Company (2,175 pp) EPA MRID 1990:416438–416401. https://archive.epa.gov/pesticides/chemicalsearch/chemical/foia/web/pdf/103601/103601-263.pdf.
Funding
The Global Glyphosate Study was supported by the Ramazzini Institute (Italy), the Heartland Health Research Alliance (USA), the Boston College (USA), the Institute for Preventive Health (USA), the Fondazione Carisbo (Italy), the Fondazione del Monte di Bologna e Ravenna (Italy), the Associazione Federide (Italy), the Coop Reno (Italy) and the Coopfond Fondo Mutualistico Legacoop (Italy).
here's an early and short version:
https://www.texasorganicresearchcenter.org/organic-research-page/Glyphosate-and-its-formulations-Roundup-Bioflow-and-RangerPro-alter-bacterial-and-fungal-community-composition-in-the-rat-caecum-microbiome_vq14502.htm
Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome
The following article was published in Front Microbio (Frontiers in Microbiology), October 5, 2022. This is an open access journal publishing under the Creative Commons Attribution license (CC-BY). The work can be freely shared and adapted provided that appropriate credit is given and any changes specified.
This journal article is freely available online so we are publishing the abstract, part of the introduction, a few quoted highlights, and conclusions. Follow the DOI link to read and/or download the entire article at doi: 10.3389/fmicb.2022.888853
Authors: Robin Mesnage, Simona Panzacchi, Emma Bourne, Charles A. Mein, Melissa J. Perry, Jianzhong Hu, Jia Chen, Daniele Mandrioli, Fiorella Belpoggi, and Michael N. Antoniou
Figure 1 Bacterial and Fungal diversity is altered in the gut microbiome of rat exposed to either glyphosate or its herbicide formulations Roundup Bioflow and RangerPro.
Abstract
The potential health consequences of glyphosate-induced gut microbiome alterations have become a matter of intense debate. As part of a multifaceted study investigating toxicity, carcinogenicity and multigenerational effects of glyphosate and its commercial herbicide formulations, we assessed changes in bacterial and fungal populations in the caecum microbiota of rats exposed prenatally until adulthood (13 weeks after weaning) to three doses of glyphosate (0.5, 5, 50 mg/kg body weight/day), or to the formulated herbicide products Roundup Bioflow and RangerPro at the same glyphosate-equivalent doses. Caecum bacterial microbiota were evaluated by 16S rRNA sequencing whilst the fungal population was determined by ITS2 amplicon sequencing. Results showed that both fungal and bacterial diversity were affected by the Roundup formulations in a dose-dependent manner, whilst glyphosate alone significantly altered only bacterial diversity. At taxa level, a reduction in Bacteroidota abundance, marked by alterations in the levels of Alloprevotella, Prevotella and Prevotellaceae UCG-003, was concomitant to increased levels of Firmicutes (e.g., Romboutsia, Dubosiella, Eubacterium brachy group or Christensenellaceae) and Actinobacteria (e.g., Enterorhabdus, Adlercreutzia, or Asaccharobacter). Treponema and Mycoplasma also had their levels reduced by the pesticide treatments. Analysis of fungal composition indicated that the abundance of the rat gut commensal Ascomycota Kazachstania was reduced while the abundance of Gibberella, Penicillium, Claviceps, Cornuvesica, Candida, Trichoderma and Sarocladium were increased by exposure to the Roundup formulations, but not to glyphosate. Altogether, our data suggest that glyphosate and its Roundup RangerPro and Bioflow caused profound changes in caecum microbiome composition by affecting the fitness of major commensals, which in turn reduced competition and allowed opportunistic fungi to grow in the gut, in particular in animals exposed to the herbicide formulations. This further indicates that changes in gut microbiome composition might influence the long-term toxicity, carcinogenicity and multigenerational effects of glyphosate-based herbicides.
Keywords: microbiota (16S), mycobiome, glyphosate, toxicity, pesticides
Introduction:
Glyphosate is a broad-spectrum herbicide active ingredient and the most used pesticide worldwide. Glyphosate-based herbicides are used to control weeds in agricultural fields and urban environments, but also to desiccate crops shortly before harvest. The use of glyphosate-based herbicides such as Roundup has increased exponentially since their introduction at the end of the 1970s due to the wide-scale adoption of glyphosate tolerant genetically modified crops, especially in North and South America (Benbrook, 2016). It is estimated that about 700,000 tons of glyphosate are used worldwide annually (Maggi et al., 2019). Although the use of glyphosate is expected to further increase by 2025 (Maggi et al., 2019), its application is reaching a plateau in some countries due to the spread of glyphosate-resistant weed species (Heap, 2014). In addition, controversies surrounding the toxicity of glyphosate has led to bans or restrictions of glyphosate usage (Robinson et al., 2020).
Highlights:
1. Analysis of alterations in fungal composition at the genus level (Supplementary Table 2) indicated that the abundance of Kazachstania (Ascomycota) was reduced while the abundance of Gibberella, Penicillium, Claviceps, Cornuvesica, Candida, Trichoderma and Sarocladium were increased by the treatments with the two Roundup formulated products (Figure 4). Glyphosate had limited effects on the mycobiome. Overall, these observations further suggest that exposure to glyphosate and its formulations affects the abundance of major bacteria taxa, which in turn reduces competition and allows opportunistic fungi to grow in the gut of the exposed animals.
2. Starting treatment at a prenatal stage of development appears to be not only more representative of real-world exposure scenarios but is apparently able to reveal effects of glyphosate and Roundup formulations that are not detected when treatment is initiated in adult animals, which have more mature and stable gut microbial communities. The adult gut microbiome is relatively stable and resilient to environmental perturbations (Lozupone et al., 2012). In contrast, the developing gut microbiome in infants appears to be more sensitive to perturbations, which could durably impact health during adult life (Robertson et al., 2019).
3. However, the changes caused by glyphosate and the two formulated products are comparable but more severe with the formulations, suggesting that the surfactants may enhance the effects of glyphosate as they do in plants in order for glyphosate to act as an efficient weedkiller. Numerous studies have shown that POEA surfactants contribute to the toxicity of glyphosate weedkillers.
Conclusion:
In conclusion, we reveal that early life exposures starting prenatally to glyphosate or its formulated products Roundup Bioflow and RangerPro cause large changes in the composition of the rat gut microbiota. This indicates that alterations in gut microbiome composition will have to be taken into account in the next phases of the Global Glyphosate Study addressing long-term toxicity, carcinogenicity and multi-generational effects of glyphosate and glyphosate -based herbicide formulations.
related titles:
Glyphosate - Chronic, Ultra-low Dose Exposure to Glyphosate in Drinking Water has Adverse Impacts on the Health of Liver and Kidneys
Glyphosate - EPA and IARC Opposing Conclusions
Glyphosate - FDA Finds Monsanto’s Weed Killer In U.S. Honey
Glyphosate - FDA Stops Testing for Glyphosate
Glyphosate - Improve Your Health by Avoiding Pesticides
Glyphosate - New Study showing Adverse Human Health and Environmental Impacts
Glyphosate - Weed Killer, Cancer, and The Corruption of Science
Glyphosate - Where is it Restricted or Banned in the United States?
Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome
Glyphosate and Roundup proven to disrupt gut microbiome by inhibiting shikimate pathway
Glyphosate Classified Carcinogenic by ICA
Glyphosate Damage - Pesticide Experts Shocking Review
Glyphosate Damage - Pesticide Experts Shocking Review
In a “state of the science” review released Tuesday, PAN International presents a large body of research documenting the adverse human health and environmental impacts of glyphosate and glyphosate-based herbicides and underscores the need for a global phase-out.
Environmental and health advocates say the monograph on the world’s most widely used herbicide, commonly known by its original trade name Roundup, should serve as a wake up call for regulators, governments and users around the world.
Adverse human impacts detailed in the review include acute poisoning, kidney and liver damage, imbalances in the intestinal microbiome and intestinal functioning, cancer, genotoxicity, endocrine disruption, reproductive and developmental reduction, neurological damage, and immune system dysfunction.
Aggressive public relations and marketing by glyphosate’s developer, Monsanto, has resulted in the widespread perception that the chemical is ‘safe’. Registration processes continue to allow its use without raising concerns about its safety even as new data identifying adverse effects emerge.
This review dispels this myth of ‘safety’ and highlights the urgent need to re-examine the authorization of products containing glyphosate. A full chemical profile is presented, along with the regulatory status of products containing glyphosate in many countries and information on viable alternatives.
Glyphosate is included in PAN International’s “List of Highly Hazardous Pesticides” targeted for global phaseout. The global network is calling for the herbicide to be replaced by agro-ecological approaches to weed management in diversified cropping systems and non-crop situations.
Glyphosate is sprayed on numerous crops and plantations, including about 80% of genetically engineered, or GE crops, as well as a pre-harvest desiccant, which results in high food residues. It is also widely used in home gardens and public places including roadsides, and semi-natural and natural habitats. Due to its widespread use residues are now detected in different types of foods, drinking water, wine and beer; and even in non-food products derived from GM cotton. The extent of human exposure is confirmed by the presence of glyphosate in human urine wherever it has been tested, principally in Europe and North America; it has also been found in breast milk in the USA.
The 2015 classification by the International Agency for Research on Cancer (IARC) of glyphosate as a probable human carcinogen resulted in widespread concern about its continued use, especially pre-harvest and in public places.
As a result, national bans and restrictions, and voluntary action by local authorities and retailers to curb use are rising dramatically. Sri Lanka was the first country to ban it completely, although the ban has recently been relaxed to allow use in tea plantations; Italy has banned pre-harvest use, and all use in public places and those frequented by children and the elderly; France is phasing out the use of pesticides in towns and public areas; and the European Union has extended approval for glyphosate for only 18 months instead of the usual 15 years. The research and evidence detailed in the review released today provides valuable scientific evidence for all communities wanting to follow these leads.
Environmental impacts detailed in the monograph are no less concerning, and include adverse effects on ecosystem functioning, pollination services, biological controls, soil fertility and crop health. Residues are widespread in the environment, including in rainwater, surface and ground waters, and the marine environment. Glyphosate can persist in some soils for up to 3 years; and there is some evidence of bioaccumulation.
Resistance to glyphosate is now recorded in 35 weed species and in 27 countries, mostly caused by the repeated use of glyphosate in GE crops, no-till agriculture, and amenity use.
The monograph also contains a useful section on alternative weed management and provides information on a wide variety of non-chemical approaches to weed management in various situations.
Keith Tyrell, Director, PAN-UK:
“This new study from PAN International’s team of scientists clearly shows that glyphosate can cause a multitude of health and environmental problems. Our regulator’s need to wake up and ban this chemical now.”
Dr Meriel Watts, PAN New Zealand:
“The time has come for global recognition of the widespread harm caused to people and the environment from the constant use of glyphosate. For too long regulators have ignored the mounting evidence of damage, hiding behind unpublished studies by Monsanto, which not surprisingly paint a picture of a benign chemical startlingly at odds with reality.”
Fernando Bejarano, PAN Mexico (RAPAM)
“The intrinsic hazards of glyphosate and their use in tolerant transgenic crops are unacceptable if we want to achieve a sustainable food system, so we need a global phase out and a shift in policies promoting instead agroecological alternatives for weed control and crop rotation in diversified crop systems.”
Dr. Peter Clausing, PAN Germany:
“In 2017 the European Chemicals Agency has to decide whether it accepts the compelling evidence for glyphosate’s carcinogenicity and declares it a carcinogen. This would be an overdue acknowledgement of the reality.”
Dr. Emily Marquez, staff scientist, PAN North America:
“The glyphosate mess illustrates the problems with industrial agriculture. Farmers are again trapped on a pesticide treadmill, as widespread adoption of Monsanto’s genetically engineered “Roundup-Ready” crops resulted in glyphosate-resistant superweeds. And yet again, human health impacts of the chemical come to light after years of widespread use. It’s time to shift away from this failing cycle of chemical reliance.”
Jayakumar Chelaton, PAN India
“Every month we get a new story of how glyphosate is harming people in the farms and off farms in rural India. It is clearly damaging people and planet.”
Sarojeni V. Rengam, PAN Asia and the Pacific
“Glyphosate is a highly hazardous pesticide. There are other ecosystem based non-chemical alternatives that do not require the use of such hazardous herbicides. We therefore urge Monsanto and other agrochemical corporations to stop the production and marketing of glyphosate in order to ensure the health of people and the environment.”
Dr Angeliki Lyssimachou, PAN Europe
“This remarkable compilation of scientific studies reveals that glyphosate-based pesticides -despite what their manufactures’ claim- are far from ‘safe’. Hundreds of non-industry funded studies show that these products are gradually poisoning our people, our environment and its ecosystems. Regulators must stop playing blind and take action to ban all uses of glyphosate.”
Posted on Oct 12 2016 - 4:29pm by Sustainable Pulse
Glyphosate Fact Sheet
Glyphosate found In 100% Of California Wines Tested - Even Some Labeled Organic
Glyphosate Found in 19 of 20 Beers and Wines Tested
Glyphosate Found in All 5 Major Orange Juice Brands
Glyphosate Found in Oat Cereal and Granola Bars
Glyphosate found in the urine of 93% of the American public recently tested
Glyphosate in Food and Water
Glyphosate Kills Lactobacillus Bacteria
Glyphosate Levels in Breakfast Foods: What is safe?
Glyphosate Persistence Raises Questions
Glyphosate Use has Risen 15-fold since 1996
Glyphosate, pathways to modern diseases: Celiac sprue and gluten intolerance
Glyphosate-based Herbicides are Toxic and Endocrine Disruptors in Human Cell Lines
Glyphosate: FDA Plan to Measure Weed Killer Residues on Food
GM Bacteria ‘Suffocates’ Soil
Roundup - California Judge enables Cancer Warning on Monsanto’s Roundup
Roundup - Court Rules Against Monsanto, Allows California To Put Cancer Warning On Roundup
Roundup - Enough to Make You Sick
Roundup - Glyphosate-based herbicide
Roundup - How Roundup Damages Your Mitochondria and Makes You Sick
Roundup - Unique Gene Expression Study Shows Massive Kidney and Liver Damage at Low Doses
Roundup - What does it do to Your Liver?
Roundup causes Liver Disease and Cancer
Roundup Creates Antibiotic Resistance
Roundup Dangers
Roundup Danish Water Contaminated
Roundup Herbicide Causes Liver Disease at Low Doses
Roundup Monsanto's Best Selling "Safe" Pesticide is Highly Toxic
Roundup More Toxic than Officially Declared - New Study
Roundup Pesticide Threat to Public Health
Roundup Poison of the Week
Roundup Reports
ROUNDUP RESIDUES ON FOOD
Roundup Resistant Weeds
Roundup Safety Assesment as Flaws
Roundup/glyphosate
Roundup: Birth Defects Caused By World's Top-Selling Weedkiller
Roundup: The “Nontoxic” Chemical that May Be Destroying our Health
Runoff blamed for jump in deformed frogs
THAT'S ABOUT A 5TH OF ALL THE ARTICLES LISTED ..........
